[HTML][HTML] Retinal stem cell transplantation: Balancing safety and potential

MS Singh, SS Park, TA Albini, MV Canto-Soler… - Progress in retinal and …, 2020 - Elsevier
Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

Advances in biomedical and pharmaceutical applications of functional bacterial cellulose-based nanocomposites

H Ullah, F Wahid, HA Santos, T Khan - Carbohydrate polymers, 2016 - Elsevier
Bacterial cellulose (BC) synthesized by certain species of bacteria, is a fascinating
biopolymer with unique physical and mechanical properties. BC's applications range from …

Consequences of oxidative stress in age-related macular degeneration

SG Jarrett, ME Boulton - Molecular aspects of medicine, 2012 - Elsevier
The retina resides in an environment that is primed for the generation of reactive oxygen
species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen …

[HTML][HTML] Stem cell treatment of degenerative eye disease

B Mead, M Berry, A Logan, RAH Scott, W Leadbeater… - Stem cell …, 2015 - Elsevier
Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …

[HTML][HTML] Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: achievements and future direction

AKL Chen, S Reuveny, SKW Oh - Biotechnology advances, 2013 - Elsevier
Mesenchymal stem cells (MSCs) have recently made significant progress with multiple
clinical trials targeting modulation of immune responses, regeneration of bone, cartilage …

Cell-based therapy technology classifications and translational challenges

NM Mount, SJ Ward, P Kefalas… - … Transactions of the …, 2015 - royalsocietypublishing.org
Cell therapies offer the promise of treating and altering the course of diseases which cannot
be addressed adequately by existing pharmaceuticals. Cell therapies are a diverse group …

Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat

AJ Carr, AA Vugler, ST Hikita, JM Lawrence, C Gias… - PloS one, 2009 - journals.plos.org
Transformation of somatic cells with a set of embryonic transcription factors produces cells
with the pluripotent properties of embryonic stem cells (ESCs). These induced pluripotent …

Stem cells in retinal regeneration: past, present and future

CM Ramsden, MB Powner, AJF Carr… - …, 2013 - journals.biologists.com
Stem cell therapy for retinal disease is under way, and several clinical trials are currently
recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem …

Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells

M Idelson, R Alper, A Obolensky, E Ben-Shushan… - Cell stem cell, 2009 - cell.com
Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of
photoreceptors in age-related macular degeneration and subtypes of retinitis pigmentosa …

Stem cell based therapies for age-related macular degeneration: the promises and the challenges

H Nazari, L Zhang, D Zhu, GJ Chader… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …