Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Abstract Growth differentiation factor 15 (GDF15), a distant member of the transforming
growth factor (TGF)-β family, is a secreted protein that circulates as a 25-kDa dimer. In …

The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …

We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …

TGF-β signaling controls a plethora of cellular responses and figures prominently in animal
development. Recent cellular, biochemical, and structural studies have revealed significant …

Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various
tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung …

Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming
growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context …