Application and value of hydrogen sulfide modulated autophagy in sepsis

Y Sun, C Liu - International Immunopharmacology, 2023 - Elsevier
Sepsis is is an abnormal host immune response caused by infection. Antibiotics, anti-viral
drugs, and vasoactive drugs have always been used in the traditional treatment of sepsis …

Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer

A Dawoud, RA Youness, K Elsayed, H Nafae… - Redox …, 2024 - Taylor & Francis
Gasotransmitters play crucial roles in regulating many physiological processes, including
cell signaling, cellular proliferation, angiogenesis, mitochondrial function, antioxidant …

Hydrogen sulfide-releasing indomethacin-derivative (ATB-344) prevents the development of oxidative gastric mucosal injuries

U Głowacka, M Magierowski, Z Śliwowski… - Antioxidants, 2023 - mdpi.com
Hydrogen sulfide (H2S) emerged recently as an anti-oxidative signaling molecule that
contributes to gastrointestinal (GI) mucosal defense and repair. Indomethacin belongs to the …

Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer

A Dawoud, RA Youness, H Nafea, T Manie… - Cancer Cell …, 2024 - Springer
Abstract Background Hydrogen sulfide (H2S) is a significant endogenous mediator that has
been implicated in the progression of various forms of cancer including breast cancer (BC) …

The role of cystathionine β-synthase in cancer

YW Wang, T Chu, XL Wang, YQ Fan, L Cao, YH Chen… - Cellular …, 2024 - Elsevier
Cystathionine β-synthase (CBS) occupies a key position as the initiating and rate-limiting
enzyme in the sulfur transfer pathway and plays a vital role in health and disease. CBS is …

[HTML][HTML] Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives

K Zhang, YW Zhu, AQ Tang, ZT Zhou, YL Yang… - Translational …, 2025 - Elsevier
The occurrence and development of tumor is mediated by a wide range of complex
mechanisms. Subsequent to nitric oxide and carbon monoxide, hydrogen sulfide (H 2 S) …

[HTML][HTML] Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers

K Matyasova, A Soltysova, P Babula… - European Journal of …, 2024 - Elsevier
Abstract The 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase,
occurring mainly in mitochondria. Although function of this protein in cancer cells has been …

Benserazide, a cystathionine beta-synthase (CBS) inhibitor, potentially enhances the anticancer effects of paclitaxel via inhibiting the S-sulfhydration of SIRT1 and the …

W Zhao, S Feng, J Wang, Z Zhang, L Chen… - Frontiers in …, 2024 - frontiersin.org
Cancer targeted therapy is essential to minimize damage to normal cells and improve
treatment outcomes. The elevated activity of Cystathionine beta-synthase (CBS), an enzyme …

The Extract of Camellia japonica L. Protects Against Mice Cerebral Ischemia/Reperfusion Injury via Promoting the H2S-BKCa Pathway

W Lu, Z Jiang, J Wen - Pharmacognosy Magazine, 2024 - journals.sagepub.com
Background and Purpose The effect and mechanism of the extract of Camellia japonica
L.(ECJ) on brain injury following cerebral ischemia/reperfusion (I/R) were demonstrated in …

[PDF][PDF] Bioinformatics analysis of the clinical value and potential mechanisms of CBS/H2S in Glioma through 1027 samples.

Y Si, N Song, Y JI - 2024 - scholar.archive.org
Background Glioma is a highly malignant brain tumor with dismal prognosis, limiting
effective treatment strategies. Thus, identifying the molecular mechanisms underlying tumor …