Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …

Single-cell proteomics by mass spectrometry is emerging as a powerful and unbiased
method for the characterization of biological heterogeneity. So far, it has been limited to …

In 2020, there have been substantial advances in nonalcoholic fatty liver disease
mechanisms, diagnostics and treatment. Key developments include the identification of a …

Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …

Background & Aims There are few in vitro models for studying the 3-dimensional interactions
among different liver cell types during organogenesis or disease development. We aimed to …

Matrix stiffening and external mechanical stress have been linked to disease and cancer
development in multiple tissues, including the liver, where cirrhosis (which increases …

Background & Aims Nonalcoholic steatohepatitis (NASH) affects patients' health-related
quality of life (HRQoL). Patient-reported outcomes (PROs) evaluating HRQoL were …

In recent years, technological advances in tissue preparation, high‐throughput volumetric
microscopy, and computational infrastructure have enabled rapid developments in …