Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Intermediates in the cholesterol-biosynthetic pathway and oxysterol derivatives of
cholesterol regulate diverse cellular processes. Recent studies have expanded the …

Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …

Parasitic diseases still constitute a major global health problem affecting billions of people
around the world. These diseases are capable of becoming chronic and result in high …

Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of
important diseases and lifelong chronic infections in humans. In the mammalian host, these …

Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse
roles in the control of cellular processes that go beyond the control of cholesterol …

Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a
variety of cells, including macrophages. For decades, NRs have been therapeutic targets …

Introduction: The two oxysterol receptors,'liver X receptors (LXRs)'LXRα and LXRβ, are
amongst the emerging newer drug targets within the nuclear receptor family and targeting …

Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be
pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of …

Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are activated
by specific oxysterols. LXRs heterodimerize with retinoid X receptors to regulate positively …