Severe asthma in children is rare, accounting for only a small proportion of childhood
asthma. After addressing modifiable factors such as adherence to treatment, comorbidities …

The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …

Background Children with moderate-to-severe asthma continue to have disease
complications despite the receipt of standard-of-care therapy. The monoclonal antibody …

Severe asthma imposes a significant burden on patients, families and healthcare systems.
Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care …

The term asthma encompasses a disease spectrum with mild to very severe disease
phenotypes whose traditional common characteristic is reversible airflow limitation. Unlike …

Although the term “asthma” has been applied to all patients with airway lability and variable
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …

Background Respiratory syncytial virus (RSV) infection is associated with subsequent
wheeze and asthma. We previously reported on the causal relationship between prevention …

abstract Severe asthma in children is associated with significant morbidity. Children with
severe asthma are at increased risk for adverse outcomes including medication-related side …

Asthma is one of the most common chronic diseases of childhood. Allergen sensitization
and high frequencies of comorbid allergic diseases are characteristic of severe asthma in …

It is largely unrecognised that the impacts of asthma are different in patients with severe
disease compared with patients with mild to moderate disease.• Severe asthma is …