Recombinant therapeutic antibodies

S Dübel - Applied microbiology and biotechnology, 2007 - Springer
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Antibody humanization methods for development of therapeutic applications

V Ahmadzadeh, S Farajnia, MAH Feizi… - Monoclonal Antibodies …, 2014 - liebertpub.com
Recombinant antibody technologies are rapidly becoming available and showing
considerable clinical success. However, the immunogenicity of murine-derived monoclonal …

Antibody variable region interactions with Protein A: implications for the development of generic purification processes

S Ghose, M Allen, B Hubbard, C Brooks… - Biotechnology and …, 2005 - Wiley Online Library
In this paper, a wide range of antibodies from various subclasses and subfamilies are
employed to evaluate the creation of generic separation processes using Protein A …

Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media

J Xu, MS Rehmann, X Xu, C Huang, J Tian, NX Qian… - MAbs, 2018 - Taylor & Francis
During biopharmaceutical process development, it is important to improve titer to reduce
drug manufacturing costs and to deliver comparable quality attributes of therapeutic …

Protein A‐based affinity chromatography

S Vunnum, G Vedantham… - Process scale purification …, 2017 - Wiley Online Library
This chapter summarizes the properties of the Protein A ligand, and reviews commercially
available Protein A resins. It discusses the development and validation of the Protein A …

Applications of ribosome display to antibody drug discovery

MAT Groves, JK Osbourn - Expert opinion on biological therapy, 2005 - Taylor & Francis
Ribosome display is a polymerase chain reaction-based invitro display technology that is
well suited to the selection and evolution of high affinity antibodies. Both eukaryotic and …

Peptibodies: Bridging the gap between peptides and antibodies

H Khezri, M Mostafavi, B Dabirmanesh… - International Journal of …, 2024 - Elsevier
Peptides are a very critical class of pharmaceutical compounds that can control several
signaling pathways and thereby affect many physiological and biochemical processes …

CD20-targeting in B-cell malignancies: novel prospects for antibodies and combination therapies

Y Safdari, V Ahmadzadeh, S Farajnia - Investigational new drugs, 2016 - Springer
Expression of CD20 antigen by the most of transformed B cells is believed to be the driving
force for targeting this molecule by using anti-CD20 monoclonal antibodies. While it is true …

Therapeutic Antibodies‐from Past to Future

S Dübel, JM Reichert - Handbook of Therapeutic Antibodies, 2014 - Wiley Online Library
Today, therapeutic antibodies represent the most rapidly growing group of protein
therapeutics, and marketed products are used to treat a very diverse set of disorders …

Generation of a rabbit single-chain fragment variable (scFv) antibody for specific detection of Bradyrhizobium sp. DOA9 in both free-living and bacteroid forms

NX Vu, N Pruksametanan, W Srila, W Yuttavanichakul… - PLoS …, 2017 - journals.plos.org
A simple and reliable method for the detection of specific nitrogen-fixing bacteria in both free-
living and bacteroid forms is essential for the development and application of biofertilizer …