[HTML][HTML] SOX2 function in cancers: Association with growth, invasion, stemness and therapy response

S Mirzaei, MDA Paskeh, M Entezari… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of death worldwide and around 10 million deaths in 2020 were
related to cancer. There are a number of therapeutic modalities for cancer such as …

FGFR families: biological functions and therapeutic interventions in tumors

Q Liu, J Huang, W Yan, Z Liu, S Liu, W Fang - MedComm, 2023 - Wiley Online Library
There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …

Role of basic fibroblast growth factor in cancer: biological activity, targeted therapies, and prognostic value

A Ardizzone, V Bova, G Casili, A Repici, M Lanza… - Cells, 2023 - mdpi.com
Cancer is the leading cause of death worldwide; thus, it is necessary to find successful
strategies. Several growth factors, such as vascular endothelial growth factor (VEGF), basic …

FGFR Alterations in Thyroid Carcinoma: A Novel Class of Primary Drivers with Significant Therapeutic Implications and Secondary Molecular Events Potentially …

MF Sabbagh, T Janovitz, D Dias-Santagata… - Thyroid, 2024 - liebertpub.com
Background: Diagnostic classification of thyroid malignancy is primarily accomplished
through examination of histomorphological features and may be substantiated and clarified …

[HTML][HTML] New advances into cisplatin resistance in head and neck squamous carcinoma: mechanisms and therapeutic aspects

H Hu, B Li, J Wang, Y Tan, M Xu, W Xu, H Lu - Biomedicine & …, 2023 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) arises from the interplay of multiple
factors, such as smoking, alcohol consumption, and viral infections. Cisplatin-based …

Therapeutic targeting of FGFR signaling in head and neck cancer

Z Wang, KS Anderson - The Cancer Journal, 2022 - journals.lww.com
Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most prevalent cancer
worldwide, with an annual incidence of 600,000 new cases. Despite advances in surgery …

Overexpression of POFUT1 promotes malignant phenotype and mediates perineural invasion in head and neck squamous cell carcinoma

N Barlak, G Kusdemir, R Gumus… - Cell biology …, 2023 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive
neoplasms, which requires more effective prevention and treatment modalities. Previous …

Enhancement of paclitaxel production by Neopestalotiopsis vitis via optimization of growth conditions

H Rezazadeh, F Ghanati, M Bonfill, F Nasibi… - Plos one, 2024 - journals.plos.org
Accessibility of paclitaxel and other taxoids from natural resources is restricted. Endophytic
fungi are novel, rapidly growing resources for producing these compounds …

Virtual screening, molecular simulations and bioassays: Discovering novel microsomal prostaglandin E Synthase-1 (mPGES-1) inhibitors

ZY Babaoglu, D Kilic - Computers in Biology and Medicine, 2023 - Elsevier
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible prostaglandin E
synthase expressed following exposure to pro-inflammatory stimuli. The mPGES-1 enzyme …

Bioinformatics approach combined with experimental verification reveals OAS3 gene implicated in paclitaxel resistance in head and neck cancer

HO Caglar, A Aytatli, N Barlak, E Aydin Karatas… - Head & …, 2024 - Wiley Online Library
Background This study aimed to identify a candidate gene associated with paclitaxel (PTX)
resistance and to evaluate functionally its biological role in the PTX‐resistant head and neck …