Among patients with asthma, heterogeneity exists regarding the pattern of airway
inflammation and response to treatment, prompting the necessity of recognizing specific …

Agonists activating β2-adrenoceptors (β2ARs) on airway smooth muscle (ASM) are the drug
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …

Animal models have been studied to unravel etiological, immunopathological, and genetic
attributes leading to asthma. However, while experiments in which the disease is artificially …

MicroRNA 143/145 (miR143/145) is restricted to adult smooth muscle cell (SMC) lineages
and mediates, in part, the expression of several SMC contractile genes. Although the …

Obesity, metabolic syndrome, and asthma are all rapidly increasing globally. Substantial
emerging evidence suggests that these three conditions are epidemiologically and …

The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM
phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the …

Smooth muscle cell (SMC) differentiation is defined largely by a number of cell-restricted
genes governed directly by the serum response factor (SRF)/myocardin (MYOCD) …

Thymic stromal lymphopoietin (TSLP) is a newly identified IL-7–like cytokine known to be
expressed in airway biopsies of patients with asthma and chronic obstructive pulmonary …

Rationale: Airway remodeling in asthma comprises increased airway smooth muscle (ASM),
an alteration linked to airway hyperresponsiveness and disease severity. Experimental …

There is a clinical need for new bronchodilator drugs in asthma, because more than half of
asthmatic patients do not receive adequate control with current available treatments. We …