The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

Spatiotemporal orchestration of gene expression is required for proper embryonic
development. The use of single-cell technologies has begun to provide improved resolution …

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Pluripotent stem cells can self-renew in culture and differentiate along all somatic lineages
in vivo. While much is known about the molecular basis of pluripotency, the mechanisms of …

Two organizing centres operate at long-range distances within the anterior neural plate to
pattern the forebrain, midbrain and hindbrain. Important progress has been made in …

In the past, attempts to create a hierarchical classification of brain structures (an ontology)
have been limited by the lack of adequate data on developmental processes. Recent studies …

The cerebellum is one of the first brain structures to begin to differentiate, yet it is one of the
last to achieve maturity—the cellular organization of the cerebellum continues to change for …

The most noticeable morphological feature of the cerebellum is its folded appearance,
whereby fissures separate its anterior-posterior extent into lobules. Each lobule is …