Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

Liver fibrosis is the final common pathway of chronic or iterative liver damage. Advanced
chronic fibrosis is described as cirrhosis with a loss of architecture and attendant functional …

Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

Group 2 innate lymphoid cells (ILC2s) and regulatory T (Treg) cells are systemically induced
by helminth infection but also sustain metabolic homeostasis in adipose tissue and …

Injury to the biliary epithelium triggers inflammation and fibrosis, which can result in severe
liver diseases and may progress to malignancy. Development of a type 1 immune response …

Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and
adaptive immunity. In recent years, many studies have shown that multiple types of …

ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells
residing in nonlymphoid tissues, and these cells can potently expand upon provision of …

ABSTRACT Interleukin-33 (IL-33) has now emerged as a cytokine with diverse and
pleiotropic functions in various infectious and inflammatory diseases. IL-33 is expressed by …

Group 2 innate lymphoid cells (ILC2) are now recognized as an important innate source of
type-2 effector cytokines. Although initially associated with mucosal tissues, it is clear that …

There is compelling evidence that inflammation contributes to tumorigenesis. Inflammatory
mediators within the tumor microenvironment can either promote an antitumor immune …