Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
Strategies, design, and chemistry in siRNA delivery systems
Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
Lipid nanoparticle technology for therapeutic gene regulation in the liver
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …
people around the globe and are a major public health burden. Most contemporary …
Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs
KJ Kauffman, JR Dorkin, JH Yang, MW Heartlein… - Nano …, 2015 - ACS Publications
Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein
production for many therapeutic applications. Although lipid nanoparticles have shown …
production for many therapeutic applications. Although lipid nanoparticles have shown …
Current status and future perspectives on MRNA drug manufacturing
C Webb, S Ip, NV Bathula, P Popova… - Molecular …, 2022 - ACS Publications
The coronavirus disease of 2019 (COVID-19) pandemic launched an unprecedented global
effort to rapidly develop vaccines to stem the spread of the novel severe acute respiratory …
effort to rapidly develop vaccines to stem the spread of the novel severe acute respiratory …
Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well
documented. Liposomes are believed to largely transport drugs into inflamed joints by …
documented. Liposomes are believed to largely transport drugs into inflamed joints by …
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver
R Zhang, R El-Mayta, TJ Murdoch, CC Warzecha… - Biomaterials …, 2021 - pubs.rsc.org
Nucleic acids, such as messenger RNAs, antisense oligonucleotides, and short interfering
RNAs, hold great promise for treating previously 'undruggable'diseases. However, there are …
RNAs, hold great promise for treating previously 'undruggable'diseases. However, there are …
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
One of the most significant challenges in the development of clinically viable delivery
systems for RNA interference therapeutics is to understand how molecular structures …
systems for RNA interference therapeutics is to understand how molecular structures …
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Dysfunctional endothelium contributes to more diseases than any other tissue in the body.
Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in …
Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in …
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
siRNA therapeutics have promise for the treatment of a wide range of genetic disorders.
Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA …
Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA …