The dopamine D4 receptor: one decade of research

JN Oak, J Oldenhof, HHM Van Tol - European journal of pharmacology, 2000 - Elsevier
Dopamine is an important neurotransmitter involved in motor control, endocrine function,
reward, cognition and emotion. Dopamine receptors belong to the superfamily of G protein …

The dopamine D4 receptor: biochemical and signalling properties

P Rondou, G Haegeman… - Cellular and molecular life …, 2010 - Springer
Dopamine is an important neurotransmitter that regulates several key functions in the brain,
such as motor output, motivation and reward, learning and memory, and endocrine …

Differential regional and cellular distribution of dopamine D2‐like receptors: an immunocytochemical study of subtype‐specific antibodies in rat and human brain

ZU Khan, A Gutiérrez, R Martín… - Journal of …, 1998 - Wiley Online Library
Dopamine D2‐like receptors (D2, D3, and D4) are major targets for action of typical and
atypical neuroleptics, commonly used in the treatment of schizophrenia. To understand their …

Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study

DTA Eisenberg, J MacKillop, M Modi… - Behavioral and Brain …, 2007 - Springer
Background Research on the genetic basis for impulsivity has revealed an array of
ambiguous findings. This may be a result of limitations to self-report assessments of …

Long-term effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

MA Berger, VG Barros, MI Sarchi, FI Tarazi… - Neurochemical …, 2002 - Springer
Prenatal stress greatly influences the ability of an individual to manage stressful events in
adulthood. Such vulnerability may result from abnormalities in the development and …

Underlying susceptibility to eating disorders and drug abuse: genetic and pharmacological aspects of dopamine D4 receptors

L Botticelli, E Micioni Di Bonaventura, F Del Bello… - Nutrients, 2020 - mdpi.com
The dopamine D4 receptor (DRD4) has a predominant expression in the prefrontal cortex
(PFC), brain area strictly involved in the modulation of reward processes related to both food …

Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex

X López-Gil, F Artigas, A Adell - Current pharmaceutical design, 2010 - ingentaconnect.com
The systemic administration of noncompetitive N-methyl-D-aspartate (NMDA) receptor
antagonists has been considered as a pharmacological model of schizophrenia. In the …

Antidepressant-like effect of D2/3 receptor-, but not D4 receptor-activation in the rat forced swim test

AM Basso, KB Gallagher, NA Bratcher… - …, 2005 - nature.com
Dopamine plays a role in the pathophysiology of depression and therapeutic effects of
antidepressants but the contribution of individual D 2-like receptor subtypes (D 2, D 3, D 4) …

Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain

VG Barros, MA Berger, ID Martijena… - Journal of …, 2004 - Wiley Online Library
Stressful stimuli during pregnancy induce complex effects that influence the development of
offspring. These effects can be prevented by environmental manipulations during the early …

Sensitivity to ageing of the limbic dopaminergic system: a review

P Barili, G De Carolis, D Zaccheo, F Amenta - Mechanisms of ageing and …, 1998 - Elsevier
The limbic system includes the complex of brain centres, nuclei and connections that
provide the anatomical substrate for emotions. Although the presence of small amounts of …