Traditional medicines have contributed greatly over the centuries to the discovery and
development of new therapeutic agents and indoloquinoline alkaloids may represent a new …

The tetracyclic indolo [3, 2-b] quinoline ring system constitutes an important structural moiety
in natural products exhibiting numerous biological activities. In particular, indolo [3, 2-b] …

Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of
quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and …

The radical Friedländer hetero-annulation of 2-aminoaryl ketone and-methylene carbonyl
compound was used to develop a green tandem approach for the metal-free synthesis of …

A highly efficient I2-promoted formal [4+ 2] cycloaddition has been developed for the
synthesis of 2-acylquinolines from methyl ketones and arylamines using 1, 4-dithane-2, 5 …

Cryptolepine (2) possesses desirable properties to serve as a lead in developing new
antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed …

As a characteristic transcription factor in solid tumors, hypoxia inducible factor-1 (HIF-1) acts
as a master regulator in breast cancer progression. Cryptolepine, as a natural alkaloid …

Quinolines and their derivatives are an important class of heterocyclic compounds that occur
widely in natural products, drugs and biologically active compounds. A large variety of …

Isosteres of cryptolepine (1) were synthesized and evaluated for their antiinfective activities.
Overall, the sulfur isostere, 5-methyl benzothieno [3, 2-b] quinolinium salt (5b), was …

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated
in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel …