Background Compassionate use is the use of unapproved drugs outside of clinical trials. So
far, compassionate use regulations have been introduced in the US, Canada, many …

Social media is fundamentally altering how we access health information and make
decisions about medical treatment, including for terminally ill patients. This specifically …

Treating physicians have key roles to play in expanded access to investigational drugs, by
identifying investigational treatment options, assessing the balance of risks and potential …

Background Targeted cancer treatments are almost always first studied in adults, even when
there is a biologically plausible potential for efficacy in children. Through compassionate use …

Importance The expanded access (EA) pathway permits patients to be treated with
investigational medical products outside clinical trials. Because cancer care is a common …

Although randomized controlled trials remain the scientific ideal for determining the efficacy
and safety of new treatments, they are sometimes insufficient to address the evidentiary …

Introduction Compassionate use of drugs is becoming increasingly popular among
terminally ill patients who require palliative care and have exhausted all treatment options …

Personalized medicines hold promise for many diseases. However, demonstrating the
clinical efficacy and cost effectiveness of these medicines can be difficult. It is essential that …

Background When a new intervention or drug is developed, this has to pass through various
phases of clinical testing before it achieves market approval, which can take many years …

The recent Ebola outbreak in West Africa began in the spring of 2014 and has since caused
the deaths of over 6,000 people. Since there are no approved treatments or prevention …