Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

The germ cell lineage originates early in development and undergoes a series of complex
developmental processes that culminate in the generation of fully matured gametes, the …

Germ cells ensure reproduction and heredity. In mice, primordial germ cells (PGCs), the
precursors for spermatozoa and oocytes, are induced in pluripotent epiblast by BMP4 and …

Germ cells are the special cells in the body that undergo meiosis to generate gametes and
subsequently entire new organisms after fertilization, a process that continues generation …

In this work we use TALE nucleases (TALENs) to target a reporter construct to the DDX4
(vasa) locus in chicken primordial germ cells (PGCs). Vasa is a key germ cell determinant in …

The Drosophila melanogaster ovary has served as a popular and successful model for
understanding a wide range of biological processes: stem cell function, germ cell …

The blastoderm is a broadly conserved stage of early animal development, wherein cells
form a layer at the embryo's periphery. The cellular behaviors underlying blastoderm …

Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult
stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these …

Extensive research into Drosophila melanogaster embryogenesis has improved our
understanding of insect developmental mechanisms. However, Drosophila development is …

Primordial germ cells (PGCs) give rise to gametes–cells necessary for the propagation and
fertility of diverse organisms. Current understanding of PGC development is limited to the …