Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020)

HA Younus, M Al-Rashida, A Hameed… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Multicomponent reactions (MCR) has been utilized to synthesize a vast range
of analogs belonging to diverse classes of heterocyclic compounds offering …

Arylglyoxals in synthesis of heterocyclic compounds

B Eftekhari-Sis, M Zirak, A Akbari - Chemical reviews, 2013 - ACS Publications
Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

Recent advancements in applications of ionic liquids in synthetic construction of heterocyclic scaffolds: A spotlight

TM Dhameliya, PR Nagar, KA Bhakhar… - Journal of Molecular …, 2022 - Elsevier
Heterocycles constitute the integral part of the most of United States food and drug
administration (USFDA) approved drugs. Over the past decade, ionic liquids have emerged …

Recent developments in the synthesis of five‐and six‐membered heterocycles using molecular iodine

PT Parvatkar, PS Parameswaran… - Chemistry–A European …, 2012 - Wiley Online Library
Heterocyclic scaffolds represent the key structural subunits of many biologically active
compounds. Over the last few years iodine‐mediated reactions have been extensively …

Synthesis of carbocyclic and heterocyclic β-aminocarboxylic acids

L Kiss, F Fülöp - Chemical Reviews, 2014 - ACS Publications
In consequence of their biological effects, conformationally constrained carbocyclic β-amino
acids have generated great interest among synthetic and medicinal chemists in the past 2 …

One-pot three-component reaction for the synthesis of pyran annulated heterocyclic compounds using DMAP as a catalyst

AT Khan, M Lal, S Ali, MM Khan - Tetrahedron Letters, 2011 - Elsevier
The one-pot three-component reaction for the synthesis of pyran annulated heterocycles is
reported by condensing aromatic aldehydes, ethyl cyanoacetate, or malononitrile and C–H …

Molecular iodine-catalyzed multicomponent reactions: an efficient catalyst for organic synthesis

YM Ren, C Cai, RC Yang - RSC advances, 2013 - pubs.rsc.org
The multicomponent reactions (MCRs) consist of two or more synthetic steps which are
carried out without isolation of any intermediate thus reducing time, saving money, energy …

A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …

S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …

Bismuth nitrate-catalyzed multicomponent reaction for efficient and one-pot synthesis of densely functionalized piperidine scaffolds at room temperature

G Brahmachari, S Das - Tetrahedron Letters, 2012 - Elsevier
A simple, straightforward, and highly efficient diastereoselective multicomponent one-pot
synthesis of a series of pharmaceutically interesting functionalized piperidine derivatives …

Cerium ammonium nitrate-catalyzed multicomponent reaction for efficient synthesis of functionalized tetrahydropyridines

HJ Wang, LP Mo, ZH Zhang - ACS Combinatorial Science, 2011 - ACS Publications
A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a
multicomponent condensation reaction of β-keto ester, two equivalents of aromatic …