Clinically relevant immunological biomarkers that discriminate between diverse
hypofunctional states of tumor-associated CD8+ T cells remain disputed. Using multiomics …

CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …

Due to their exceptional properties and cost effectiveness, polyamides or nylons have
emerged as widely used materials, revolutionizing diverse industries, including industrial 3D …

Mass-spectrometry-based proteomics presents some unique challenges for batch effect
correction. Batch effects are technical sources of variation, can confound analysis and …

Preclinical models have been the workhorse of cancer research, producing massive
amounts of drug response data. Unfortunately, translating response biomarkers derived from …

Multiple sequence alignment (MSA) is a critical step in the study of protein sequence and
function. Typically, MSA algorithms progressively align pairs of sequences and combine …

Additive manufacturing (AM) or industrial 3D printing uses cutting-edge technologies and
materials to produce a variety of complex products. However, the effects of the …

Ferroptosis is a caspase-independent, iron-dependent form of regulated necrosis extant in
traumatic brain injury, Huntington disease, and hemorrhagic stroke. It can be activated by …

The mechanisms by which DNA alleles contribute to disease risk, drug response, and other
human phenotypes are highly context-specific, varying across cell types and different …

Functional selectivity in the context of serotonin 2A (5-HT2A) receptor agonists is often
described as differences psychedelic compounds have in the activation of Gq vs β-arrestin …