Sulfoxides have emerged as pivotal constituents in modern carbohydrate chemistry. As
anomeric leaving groups, sulfinyl moieties may occupy positions directly at the anomeric …

Minimal structural differences in the structure of glycosyl donors can have a tremendous
impact on their reactivity and the stereochemical outcome of their glycosylation reactions …

Attaining complete anomeric control is still one of the biggest challenges in carbohydrate
chemistry. Glycosyl cations such as oxocarbenium and dioxanium ions are key …

Abstract The stereoselective formation of 1, 2-cis glycosidic linkages is challenging. The
currently most widely used strategy for their installation uses 4, 6-O-benzylidene-protected …

The outcome of glycosylation reactions heavily relies on the specific protecting group
patterns employed on both the donor and acceptor molecules. The picoloyl (Pico) protecting …

The development of a continuous flow reactor for stereospecific glycosylation reactions with
deoxy sugars is described. This apparatus that permits optimizing the selectivity of …

Minimal structural differences in the structure of glycosyl donors can have a tremendous
impact on their reactivity and the stereochemical outcome of their glycosylation reactions. It …

L–Idose thioglycosides are useful glycosyl donors for the construction of glycosaminoglycan
oligosaccharides. When activated with NIS and catalytic TMSOTf in the presence of …

Elucidating the molecular mechanisms of chemical O-glycosylation remains a significant
challenge in glycochemistry. This study examines the mechanism of the nucleophilic …

Carbohydrates, along with their derivatives known as glycoconjugates, represent the largest
and most varied group of biological molecules found in nature, being present in all life forms …