The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

The classical biogenic amine neurotransmitters—dopamine, noradrenaline, and 5-
hydroxytryptamine—control a variety of functions including locomotion, autonomic function …

SERT is of interest also as a drug target. A variety of compounds that are used to treat
clinical depression, including fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil) and …

Using cysteine cross-linking, we demonstrated previously that the dopamine transporter
(DAT) is at least a homodimer, with the extracellular end of transmembrane segment (TM) 6 …

Binding of Zn2+ to the endogenous Zn2+ binding site in the human dopamine transporter
leads to potent inhibition of [3H] dopamine uptake. Here we show that mutation of an …

Serotonin transporter (SERT) catalyzes reuptake of the neurotransmitter serotonin (5-HT)
and is a target for antidepressant drugs and psychostimulants. It is a member of a large …

Solute transport across cell membranes is ubiquitous in biology as an essential
physiological process. Secondary active transporters couple the unfavorable process of …

Heteromeric amino acid transporters are composed of a heavy and a light subunit linked by
a disulfide bridge. 4F2hc/xCT elicits sodium-independent exchange of anionic l-cysteine …

Recently we showed evidence that mutation of Tyr-335 to Ala (Y335A) in the human
dopamine transporter (hDAT) alters the conformational equilibrium of the transport cycle …

Uptake of neurotransmitters by sodium-coupled monoamine transporters of the NSS family
is required for termination of synaptic transmission. Transport is tightly regulated by protein …