Mycobacterial PE/PPE proteins at the host‐pathogen interface
SL Sampson - Journal of Immunology Research, 2011 - Wiley Online Library
The mycobacterial PE/PPE proteins have attracted much interest since their formal
identification just over a decade ago. It has been widely speculated that these proteins may …
identification just over a decade ago. It has been widely speculated that these proteins may …
[HTML][HTML] Tuberculosis vaccines–state of the art, and novel approaches to vaccine development
C da Costa, B Walker, A Bonavia - International Journal of Infectious …, 2015 - Elsevier
The quest for a vaccine that could have a major impact in reducing the current global burden
of TB disease in humans continues to be extremely challenging. Significant gaps in our …
of TB disease in humans continues to be extremely challenging. Significant gaps in our …
[HTML][HTML] A novel vaccine against Crimean-Congo Haemorrhagic Fever protects 100% of animals against lethal challenge in a mouse model
KR Buttigieg, SD Dowall, S Findlay-Wilson… - PloS one, 2014 - journals.plos.org
Crimean-Congo Haemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in
many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of …
many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of …
Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis
S Bertholet, GC Ireton, M Kahn, J Guderian… - The Journal of …, 2008 - journals.aai.org
Abstract Development of a subunit vaccine for Mycobacterium tuberculosis (Mtb) depends
on the identification of Ags that induce appropriate T cell responses. Using bioinformatics …
on the identification of Ags that induce appropriate T cell responses. Using bioinformatics …
A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
SD Dowall, KR Buttigieg… - Human vaccines & …, 2016 - Taylor & Francis
Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in
many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of …
many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of …
[HTML][HTML] Whole genome identification of Mycobacterium tuberculosisvaccine candidates by comprehensive data mining and bioinformatic analyses
A Zvi, N Ariel, J Fulkerson, JC Sadoff… - BMC medical …, 2008 - Springer
Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects~ 8
million annually culminating in~ 2 million deaths. Moreover, about one third of the …
million annually culminating in~ 2 million deaths. Moreover, about one third of the …
[HTML][HTML] Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective …
CRE McEvoy, R Cloete, B Müller, AC Schürch… - PloS one, 2012 - journals.plos.org
Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families
termed pe and ppe. The function of pe/ppe proteins remains enigmatic but studies suggest …
termed pe and ppe. The function of pe/ppe proteins remains enigmatic but studies suggest …
Vaccination against paratuberculosis
V Rosseels, K Huygen - Expert review of vaccines, 2008 - Taylor & Francis
Johne's disease, or paratuberculosis, is a chronic granulomatous enteritis in ruminants
caused by Mycobacterium avium subsp. paratuberculosis (MAP) affecting principally cattle …
caused by Mycobacterium avium subsp. paratuberculosis (MAP) affecting principally cattle …
PE and PPE genes: a tale of conservation and diversity
G Delogu, MJ Brennan, R Manganelli - Strain Variation in the …, 2017 - Springer
PE and PPE are two large families of proteins typical of mycobacteria whose structural
genes in the Mycobacterium tuberculosis complex (MTBC) occupy about 7% of the total …
genes in the Mycobacterium tuberculosis complex (MTBC) occupy about 7% of the total …
Evaluation of new vaccines for tuberculosis in the guinea pig model
A Williams, Y Hall, IM Orme - Tuberculosis, 2009 - Elsevier
The guinea pig is a very useful animal model for evaluating new tuberculosis candidate
vaccines. In addition to established methods for bacterial load determinations, new …
vaccines. In addition to established methods for bacterial load determinations, new …