G-quadruplexes (G4s) are unique non-canonical four-stranded nucleic acid secondary
structures formed by guanine-rich DNA or RNA sequences. Sequences with the potential to …

Biophysical and biochemical investigations provide compelling evidence connecting the
four-stranded G-quadruplex (GQ) structure with its role in regulating multiple cellular …

Rif1 regulates replication timing and repair of double-strand DNA breaks. Using a chromatin
immunoprecipitation–sequencing method, we identified 35 high-affinity Rif1-binding sites in …

DNA i-motifs (iMs) are non-canonical C-rich secondary structures implicated in numerous
cellular processes. Though iMs exist throughout the genome, our understanding of iM …

In the present study, our bioinformatics analysis first reveals the existence of a conserved
guanine-rich sequence within the Zaire ebolavirus L gene. Using various methods, we show …

Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4)
structures. While cellular proteins and small molecules can bind G4s, it has been difficult to …

Cancer stem cells (CSCs) are responsible for drug resistance, metastasis and recurrence of
cancers. However, there is still no clinically approved drug that can effectively eradicate …

Abstract Development of probes that can discriminate G-quadruplex (GQ) structures and
indentify efficient GQ binders on the basis of topology and nucleic acid type is highly desired …

Abstract RNA G-quadruplexes (G4s) are one of the key components of the transcriptome that
act as efficient post-transcriptional regulatory elements in living cells. To conduct further …

Abstract G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-
rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often …