Introduction: The development of novel complex biotherapeutics led to new challenges in
biopharmaceutical industry. The potential of these particles has been demonstrated by the …

The economic advantages of continuous processing of biopharmaceuticals, which include
smaller equipment and faster, efficient processes, have increased interest in this technology …

The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …

Simulated Moving Bed Technology is one of only a few books solely dedicated to SMB. It
aims to equip you with the tools and skills needed for SMB modelling, simulation, design …

Continuous production delivers higher productivity and better quality than traditional batch-
wise approaches. It intensifies production lowering capital cost and enables better control …

In recent years, the development of novel recombinant virus‐like particles (VLPs) has been
generating new perspectives for the prevention of untreated and arising infectious diseases …

Viral vectors are poised to acquire a prominent position in modern medicine and
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …

Several chromatographic approaches have been established over the last decades for the
production of pharmaceutically relevant viruses. Due to the large size of these products …

Replacing batch unit operations of biopharmaceuticals by continuous manufacturing is a
maturing concept, with periodic counter-current chromatography (PCC) favoured to replace …

Viruses still pose a significant threat to human and animal health worldwide. In the fight
against viral infections, high-purity viral stocks are needed for manufacture of safer vaccines …