Psilocybin is a classic psychedelic with demonstrated preliminary clinical efficacy in a range
of psychiatric disorders. Evaluating the impact of psilocybin on cognitive function is essential …

For 3000 years, psychedelics have been used in religious contexts to enhance spiritual
thinking, well-being, and a sense of community. In the last few years, a renaissance in the …

Bufalin is a promising active ingredient in traditional Chinese medicine but has shown
limited anticancer applications due to its toxicity. Here, we report BCNPs@ gel, a bufalin …

Although aminergic GPCRs are the target for~ 25% of approved drugs, developing subtype
selective drugs is a major challenge due to the high sequence conservation at their …

Tropane-containing small molecules like scopolamine are a promising class of
psychoplastogens. However, their potent antagonism of all muscarinic receptor subtypes …

Threatening events and stressful experiences can lead to maladaptive memories and
related behaviors. Existing treatments often fail to address these issues linked to …

Antidepressant drugs promote neuronal plasticity, and activation of brainderived
neurotrophic factor (BDNF) signaling through its receptor neuronal receptor tyrosine kinase …

Lysergic acid (LA) is the basic precursor for the biosynthesis of various ergot alkaloids of
pharmaceutical importance. The heterologous biosynthesis of LA in microbes is a promising …

Neuroinflammation is a critical factor in the pathogenesis of various neurodegenerative and
psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and major …

5-methoxy-N, N-dimethyltrytpamine (5-MeO-DMT) analogs are used as recreational drugs,
but they are also being developed as potential medicines, warranting further investigation …