Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Cardiovascular disease (CVD)-related mortality and morbidity are among the most critical
disease burdens worldwide. CVDs encompass many diseases and involve complex …

Hypertension, a disease with known sexual dimorphism, accelerates aging-associated
arterial stiffening, partly because of the activation of matrix remodeling caused by increased …

Aortic stiffening is an inevitable manifestation of chronological aging, yet the mechano‐
molecular programs that orchestrate region‐and layer‐specific adaptations along the length …

During sterile inflammation, tissue damage induces excessive activation and infiltration of
neutrophils into tissues, where they critically contribute to organ dysfunction. Tight regulation …

Microglia, as resident immune cells in the central nervous system (CNS), play a crucial role
in maintaining homeostasis and phagocytosing metabolic waste in the brain. Senescent …

Simple Summary The immune and circulatory systems of insects are functionally integrated.
An infection induces the migration of immune cells called hemocytes to the surface of the …

Hypoxia in the neonatal period is associated with early manifestations of adverse
cardiovascular health in adulthood including higher risk of hypertension and …

Background: Hypertension, a disease with known sexual dimorphism, accelerates aging
associated arterial stiffening, in part due to the activation of matrix remodeling caused by …

Background: Normal endothelial cell dependent vascular smooth muscle cell function is
mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of …