Sea stars resist wasting through active immune and collagen systems

MH Pespeni, MM Lloyd - Proceedings of the Royal …, 2023 - royalsocietypublishing.org
Epidemics are becoming more common and severe, however, pinpointing the causes can
be challenging, particularly in marine environments. The cause of sea star wasting (SSW) …

RNA oxidation in chromatin modification and DNA-damage response following exposure to formaldehyde

JC Gonzalez-Rivera, MW Sherman, DS Wang… - Scientific Reports, 2020 - nature.com
Formaldehyde is an environmental and occupational chemical carcinogen implicated in the
damage of proteins and nucleic acids. However, whether formaldehyde provokes …

Endogenous microRNA triggered enzyme-free DNA logic self-assembly for amplified bioimaging and enhanced gene therapy via in situ generation of siRNAs

Q Jiang, S Yue, K Yu, T Tian, J Zhang, H Chu… - Journal of …, 2021 - Springer
Abstract Background Small interfering RNA (siRNA) has emerged as a kind of promising
therapeutic agents for cancer therapy. However, the off-target effect and degradation are the …

Computational approaches in design of nucleic acid-based therapeutics

M Sherman, L Contreras - Current opinion in biotechnology, 2018 - Elsevier
Highlights•Nucleic acid-based drugs have been established as a promising potential
therapeutic.•Nucleic acid-based drugs can enable new modes of therapeutic chemistries.• …

Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes

JC Gonzalez-Rivera, KC Baldridge, DS Wang… - Communications …, 2020 - nature.com
The impact of environmentally-induced chemical changes in RNA has been fairly
unexplored. Air pollution induces oxidative modifications such as 8-oxo-7, 8-dihydroguanine …

[HTML][HTML] Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding

JC Gonzalez-Rivera, AA Orr, SM Engels… - Computational and …, 2020 - Elsevier
The oxidation of RNA has been implicated in the development of many diseases. Among the
four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the …

[HTML][HTML] A comparative analysis of machine learning classifiers for predicting protein-binding nucleotides in RNA sequences

A Agarwal, K Singh, S Kant, RP Bahadur - Computational and Structural …, 2022 - Elsevier
RNA-protein interactions play vital roles in driving the cellular machineries. Despite
significant involvement in several biological processes, the underlying molecular …

[HTML][HTML] Cryptic splicing events result in unexpected protein products from calpain-10 (CAPN10) cDNA

Y Ono, N Doi, M Shindo, P Pánico… - Biochimica et Biophysica …, 2022 - Elsevier
Abstract Calpain-10 (CAPN10) belongs to the calpain superfamily. Genetic polymorphisms
of the CAPN10 gene are associated with susceptibility to develop type 2 diabetes mellitus …

A high-throughput and rapid computational method for screening of RNA post-transcriptional modifications that can be recognized by target proteins

AA Orr, JC Gonzalez-Rivera, M Wilson, PR Bhikha… - Methods, 2018 - Elsevier
There are over 150 currently known, highly diverse chemically modified RNAs, which are
dynamic, reversible, and can modulate RNA-protein interactions. Yet, little is known about …

[HTML][HTML] Trajectories of RNA Virus Mutation Hidden by Evolutionary Alternate Reality Thermodynamic Endpoints in Transformations in Response to Abiotic Habitat …

FH Campbell - Environmental Management-Pollution, Habitat …, 2021 - intechopen.com
Viruses ensure the vital redistribution of nutrients to maintain sustainability in an ecosystem.
This includes repair and survival, growth and evolution thanks to the efficient nutrient …