Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …

Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

α-Synuclein is central in Parkinson's disease pathogenesis. Although initially α-synuclein
was considered a purely intracellular protein, recent data suggest that it can be detected in …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of
Parkinson's disease patients, but still little is understood about how it is regulated or …

Protein–protein interactions (PPIs) underlie most biological processes. An increasing
interest to investigate the unexplored potential of PPIs in drug discovery is driven by the …

One of the most strikingrags to riches' stories in the protein world is that of 14-3-3, originally
identified in 1967 as merely an abundant brain protein. The first clues that 14-3-3 would play …

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed
in all eukaryotic cells. These proteins participate in a variety of intracellular processes by …

14-3-3-interacting proteins were isolated from extracts of proliferating HeLa cells using 14-3-
3 affinity chromatography, eluting with a phosphopeptide that competes with targets for 14-3 …