Recent advances of tubulin inhibitors targeting the colchicine binding site for cancer therapy
M Hawash - Biomolecules, 2022 - mdpi.com
Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents, an update (2013–2015)
R Patil, SA Patil, KD Beaman… - Future Medicinal Chemistry, 2016 - Taylor & Francis
Discovery of new indole-based tubulin polymerization inhibitors will continue to dominate
the synthetic efforts of many medicinal chemists working in the field. The indole ring system …
the synthetic efforts of many medicinal chemists working in the field. The indole ring system …
Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines
Background Liver cancer is predicted to be the sixth most diagnosed cancer globally and
fourth leading cause of cancer deaths. In this study, a series of indole-3-isoxazole-5 …
fourth leading cause of cancer deaths. In this study, a series of indole-3-isoxazole-5 …
Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
Abstract Structurally diverse indole-3-pyrazole-5-carboxamide analogues (10-29) were
designed, synthesized, and evaluated for their antiproliferative activity against three cancer …
designed, synthesized, and evaluated for their antiproliferative activity against three cancer …
Synthesis and Biological Evaluation of Novel Isoxazole‐Amide Analogues as Anticancer and Antioxidant Agents
Cancer now is one of the leading causes of mortality in the world. There has been a lot of
effort to discover new anticarcinogenic agents that allow treatment with fewer side effects. A …
effort to discover new anticarcinogenic agents that allow treatment with fewer side effects. A …
Evaluation of cytotoxic, COX inhibitory, and antimicrobial activities of novel isoxazole-carboxamide derivatives
Isoxazole derivatives are one of the heterocyclic structures that have various biological
activities. Objective: This study aimed to design and synthesize novel isoxazole derivatives …
activities. Objective: This study aimed to design and synthesize novel isoxazole derivatives …
Synthesis and biological evaluation of imidazo [2, 1-b] thiazole-benzimidazole conjugates as microtubule-targeting agents
MF Baig, VL Nayak, P Budaganaboyina, K Mullagiri… - Bioorganic …, 2018 - Elsevier
Abstract A series of imidazo [2, 1-b] thiazole-benzimidazole conjugates were synthesized
and evaluated for their antiproliferative activity against four human cancer cell lines ie; HeLa …
and evaluated for their antiproliferative activity against four human cancer cell lines ie; HeLa …
Synthesis of (Z)-1-(1, 3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino) prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents
Abstract A series of (Z)-1-(1, 3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino) prop-2-en-1-one
derivatives were synthesized and characterized by 1 H and 13 C NMR, ESI-MS and HRMS …
derivatives were synthesized and characterized by 1 H and 13 C NMR, ESI-MS and HRMS …
Synthesis, chemo-informatics, and anticancer evaluation of fluorophenyl-isoxazole derivatives
The current study aimed to design and synthesize a novel series of fluorophenyl-isoxazole-
carboxamide derivatives and evaluate their antiproliferative activities. Anticancer activities of …
carboxamide derivatives and evaluate their antiproliferative activities. Anticancer activities of …
Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review
In the present era, the concept of green in organic synthesis has a unique and irreplaceable
place. Specifically, nanoparticle has gained much more attention due to its various …
place. Specifically, nanoparticle has gained much more attention due to its various …