[HTML][HTML] BK Polyomavirus Infection in Kidney Transplantation: A Comprehensive Review of Current Challenges and Future Directions

N Nourie, C Boueri, H Tran Minh, G Divard… - International Journal of …, 2024 - mdpi.com
BK polyomavirus (BKPyV) infection of the kidney graft remains a major clinical issue in the
field of organ transplantation. Risk factors for BKPyV-associated nephropathy (BKPyVAN) …

Urine CXCL10 as a biomarker in kidney transplantation

P Hirt-Minkowski, S Schaub - Current Opinion in Organ …, 2024 - journals.lww.com
Urine CXCL10 is a well characterized inflammation biomarker, which can be used to guide
performance of surveillance biopsies. Wide implementation into clinical practice depends on …

Single-cell RNA-sequencing of BK polyomavirus replication in primary human renal proximal tubular epithelial cells identifies specific transcriptome signatures and a …

FH Weissbach, OM Follonier, S Schmid… - Journal of …, 2024 - journals.asm.org
ABSTRACT BK polyomavirus (BKPyV) contributes to premature renal failure in 10%–20% of
kidney transplant recipients. Current treatment relies on reducing immunosuppression to …

JCPyV infection of primary choroid plexus epithelial cells reduces expression of critical junctional proteins and increases expression of barrier disrupting inflammatory …

SA Haley, BA O'Hara, C Schorl… - Microbiology Spectrum, 2024 - Am Soc Microbiol
The human polyomavirus, JCPyV, establishes a lifelong persistent infection in the peripheral
organs of a majority of the human population worldwide. Patients who are …

Risk of cellular or antibody-mediated rejection in pediatric kidney transplant recipients with BK polyomavirus replication—an international CERTAIN registry study

A Fichtner, J Schmidt, C Süsal, A Carraro, J Oh… - Pediatric …, 2024 - Springer
Background In kidney transplant recipients (KTR), BK polyomavirus-associated nephropathy
(BKPyVAN) is a major cause of graft loss. To facilitate the clearance of BKPyV-DNAemia …

Optimizing the approach to monitoring allograft inflammation using serial urinary CXCL10/creatinine testing in pediatric kidney transplant recipients

E Barrett‐Chan, L Wang, J Bone… - Pediatric …, 2024 - Wiley Online Library
Abstract Background Urinary CXCL10/creatinine (uCXCL10/Cr) is proposed as an effective
biomarker of subclinical rejection in pediatric kidney transplant recipients. This study …

BK polyomavirus infection: more than 50 years and still a threat to kidney transplant recipients

S Parajuli, F Aziz, W Zhong, A Djamali - Frontiers in Transplantation, 2024 - frontiersin.org
BK polyomavirus (BKPyV) is a ubiquitous human polyomavirus and a major infection after
kidney transplantation, primarily due to immunosuppression. BKPyV reactivation can …

Authors' Reply: Of End Points and Context of Use: A Reasonable Silver Lining for Urinary Chemokines Monitoring

P Hirt-Minkowski, C Wehmeier… - Journal of the American …, 2023 - journals.lww.com
See related letter to the editor,“Of Endpoints and Context of Use: A Reasonable Silver Lining
for Urinary Chemokines Monitoring,” on pages 1765–1766 and original article,“Randomized …

Urine CXCL10 Levels as a Predictor for Various Phases of BKPyV Replication Among Kidney Transplant Recipients: Utility and Clinical Implementation

S Parajuli, D Mandelbrot - Transplantation, 2023 - journals.lww.com
Although BK polyomavirus (BKPyV) was first isolated from the urine of a kidney transplant
recipient> 50 y ago, to date, no prophylactic strategy or effective antiviral therapy exists. The …

BK Virus-Associated Nephropathy in Adult Patients Post Kidney Transplantation: What Progress in 30 Years of History?

Y Bentata - OBM Transplantation, 2024 - lidsen.com
Completely unknown before the 90s and exceptional up to the 2000s, BK virus nephropathy
(BKvN), usually known as polyomavirus-associated nephropathy, has emerged as a …