While plants are an abundant source of valuable natural products, it is often challenging to
produce those products for commercial application. Often organic synthesis is too expensive …

Plants produce a range of secondary metabolites primarily as defence molecules. A plant
has to invest considerable energy to synthesise alkaloids, and sometimes they are even …

Catharanthus roseus leaves produce a range of monoterpenoid indole alkaloids (MIAs) that
include low levels of the anticancer drugs vinblastine and vincristine. The MIA pathway …

Plant‐specialized metabolism is largely driven by the oxidative tailoring of key chemical
scaffolds catalyzed by cytochrome P450 (CYP450s) enzymes. Monoterpene indole alkaloids …

In plants, the biosynthetic pathways of some specialized metabolites are partitioned into
specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) …

Catharanthus roseus is a perennial herb of the Apocynaceae family, from which about 200
kinds of alkaloids have been characterized. Most alkaloids from C. roseus are terpenoid …

In Catharanthus roseus, monoterpenoid indole alkaloids (MIAs) are produced through the
cooperation of four cell types, with final products accumulating in specialized cells known as …

Transcription factors (TFs) provide potentially powerful tools for plant metabolic engineering
as they often control multiple genes in a metabolic pathway. However, selecting the best TF …

Key message A GLK homologue was identified and functionally characterized in
Catharanthus roseus. Silencing CrGLK with VIGS or the chloroplast retrograde signaling …

Abstract Key Message The C. roseus ZCTs are jasmonate-responsive, can be induced by
CrMYC2a, and can act as significant regulators of the terpenoid indole alkaloid pathway …