Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the
mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its …

Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that arises from the cells
lining the tubes of the kidney. The tumor immune microenvironment (TIME) of ccRCC is a …

Purpose: Patients presenting with microhematuria represent a heterogeneous population
with a broad spectrum of risk for genitourinary malignancy. Recognizing that patient-specific …

To maximize the impact of precision medicine approaches, it is critical to identify genetic
variants underlying disease and to accurately quantify their functional effects. A gene …

Simple Summary Over the past two decades, biological discoveries have transformed the
treatment strategies for renal cell carcinoma. These advances have led to the development …

The number of patients surviving≥ 5 years after initial cancer diagnosis has significantly
increased during the last decades due to considerable improvements in the treatment of …

The association between chronic kidney disease (CKD) and renal cell carcinoma (RCC) is
bidirectional and multifactorial. Risk factors such as hypertension, diabetes mellitus, obesity …

Purpose Neuroendocrine neoplasms can occur as part of inherited disorders, usually in the
form of well-differentiated, slow-growing tumors (NET). The main predisposing syndromes …

The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating
catabolic conversions of NAD+ to NADH and anabolic production of aspartate, a key amino …

Heart failure (HF) and cancer are the leading causes of death worldwide and accumulating
evidence demonstrates that HF and cancer affect one another in a bidirectional way …