Synthesis of biologically active molecules through multicomponent reactions

D Insuasty, J Castillo, D Becerra, H Rojas, R Abonia - Molecules, 2020 - mdpi.com
Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

Emerging impact of triazoles as anti-tubercular agent

A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Design, synthesis, and antimicrobial activities of 1, 2, 3-triazole glycoside clickamers

T El Malah, HF Nour, AAE Satti, BA Hemdan… - Molecules, 2020 - mdpi.com
Bacterial resistance remains a significant threat and a leading cause of death worldwide,
despite massive attempts to control infections. In an effort to develop biologically active …

Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions

TM Dhameliya, KA Bhakhar, ND Gajjar, KA Patel… - Journal of Molecular …, 2022 - Elsevier
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …

A review on molecular iodine catalyzed/mediated multicomponent reactions

Monika, Chander, S Ram… - Asian Journal of Organic …, 2023 - Wiley Online Library
In multicomponent reactions, three or more reactants combine in one pot to form a product
without the isolation of intermediate and most of the reactants contribute to newly formed …

Dimers of coumarin-1, 2, 3-triazole hybrids bearing alkyl spacer: Design, microwave-assisted synthesis, molecular docking and evaluation as antimycobacterial and …

D Ashok, S Gundu, VK Aamate, MG Devulapally… - Journal of Molecular …, 2018 - Elsevier
The present study demonstrated the synthesis of new series of coumarin-1, 2, 3-triazole
hybrids under microwave irradiation method. Several dimers of coumarin based 1, 2, 3 …

[HTML][HTML] Thiazole, triazole, thio-and semicarbazone derivatives-Promising moieties for drug development for the treatment of tuberculosis

CB Scarim, FR Pavan - European Journal of Medicinal Chemistry Reports, 2021 - Elsevier
Thiazole, triazole, thio and semicarbazones are privileged motifs that act as
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …

Design, synthesis and molecular docking studies of novel triazole‐chromene conjugates as antitubercular, antioxidant and antifungal agents

SP Khare, TR Deshmukh, JN Sangshetti… - …, 2018 - Wiley Online Library
A green and efficient protocol has been developed for the synthesis of novel 1, 2, 3‐triazole‐
chromene conjugates (7 a‐j) via ultrasound assisted and NaHCO3 catalyzed for the first …

Ultrasound assisted rapid synthesis, biological evaluation, and molecular docking study of new 1,2,3-triazolyl pyrano[2,3-c]pyrazoles as antifungal and antioxidant …

SP Khare, TR Deshmukh, JN Sangshetti… - Synthetic …, 2019 - Taylor & Francis
In search of new generation of triazole based antifungal agents, synthesis of series of new 1,
2, 3-triazolyl pyrano [2, 3-c] pyrazoles under ultrasonic irradiation using NaHCO3 has been …

Opportunities and challenges of using five‐membered ring compounds as promising antitubercular agents

M Yan, L Xu, Y Wang, J Wan, T Liu… - Drug Development …, 2020 - Wiley Online Library
Tuberculosis (TB), a chronic infectious disease, is one of the greatest risks to human beings
and 10 million people were diagnosed with TB and 1.6 million died from this disease in …