Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …

The 9th Banff Conference on Allograft Pathology was held in La Coruna, Spain on June 23–
29, 2007. A total of 235 pathologists, clinicians and scientists met to address unsolved …

Background The relationship between the donor-derived cell-free DNA fraction (dd-cfDNA
[%]) in plasma in kidney transplant recipients at time of indication biopsy and gene …

Antibody‐mediated rejection is the major cause of kidney transplant failure, but the histology‐
based diagnostic system misses most cases due to its requirement for C4d positivity. We …

The authors conducted a prospective trial to assess the feasibility of real time central
molecular assessment of kidney transplant biopsy samples from 10 North American or …

The prevalent renal transplant population presents an opportunity to observe the adaptive
changes in the alloimmune response over time, but such studies have been limited by …

Progress in renal transplantation requires improved understanding and assessment of
rejection and injury. Study of the relationship between gene expression and clinical …

Histologic diagnosis of T cell-mediated rejection is flawed by subjective assessments,
nonspecific lesions and arbitrary rules. This study developed a molecular test for T cell …

Background In early estrogen receptor (ER)-positive/HER2-negative breast cancer, the
decision to administer chemotherapy is largely based on prognostic criteria. The combined …