In this review we highlight the most modern trends in the prodrug strategy. In drug research
and development, the prodrug concept has found a number of useful applications. Selected …

Cancer is widely recognized as one of the most devastating diseases, necessitating the
development of intelligent diagnostic techniques, targeted treatments, and early prognosis …

What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …

At the intersection of nucleic acid and boron chemistries lies a thriving world of possibilities.
During the past decades, the merging of these research domains has led to fascinating …

In aqueous solution, host–guest complexation is frequently driven by the hydrophobic effect,
which also constitutes a popular approach in the design of supramolecular assemblies …

Cancer is a leading cause of death worldwide, and the main treatment methods for this
condition are surgery, chemotherapy, and radiotherapy. These treatment methods are …

The purpose of the present study was to evaluate the effectiveness of a 3-carboranyl
thymidine analogue (3CTA), 3-[5-{2-(2, 3-dihydroxyprop-1-yl)-o-carboran-1-yl} pentan-1-yl] …

A library of sixteen 2nd generation amino-and amido-substituted carboranyl pyrimidine
nucleoside analogs, designed as substrates and inhibitors of thymidine kinase 1 (TK1) for …

Introduction: Dendrimers were widely used in cancer diagnosis and therapy during the past
decade. The surface functionalities allow bioactive molecules such as imaging probes …

Nucleosides containing carboranes are one of the most important boron delivery agents for
boron neutron capture therapy, BNCT, which are good substrates of hTK1. The development …