Recombinant adeno-associated viral vectors (AAVs) are an effective system for gene
transfer. AAV serotype 2 (AAV2) is commonly used to deliver transgenes to retinal ganglion …

Axon loss underlies symptom onset and progression in many neurodegenerative disorders.
Axon degeneration in injury and disease is promoted by activation of the NAD-consuming …

Background Vascular dysregulation is one of the major risk factors of glaucoma, and
endothelin-1 (ET-1) may have a role in the pathogenesis of vascular-related glaucoma. Fruit …

Glaucoma is characterized by the progressive loss of retinal ganglion cells (RGCs), although
the pathogenic mechanism remains largely unknown. To study the mechanism and assess …

The wiring of visual circuits requires that retinal neurons functionally connect to specific
brain targets, a process that involves activity-dependent signaling between retinal axons …

Axon loss underlies symptom onset and progression in many neurodegenerative disorders.
Axon degeneration in injury and disease is promoted by activation of the nicotinamide …

The development of a non-invasive method for measuring the internal fluid behavior and
dynamics of microchannels in microfluidics poses critical challenges to biological research …

Immunofluorescence is used in numerous research areas including eye research to detect
specific antigens in cells and tissues. One limitation is that fluorescent signal can fade …

It is developed a plugin for ImageJ that performs global thresholding through four innovative
thresholding algorithms, which are designed last five years. These algorithms are …

Purpose: To study the long-term effects of endothelin-1 (ET-1)–induced retinal pathologies
in mouse, using clinically relevant tools. Methods: Adult C57BL/6 mice (7–9 weeks old) were …