Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000
different proteins and is closely related to the development of cells. However, damaged …

Mitochondrial high-temperature requirement protease A2 (HtrA2) is an integral member of
the HtrA family of serine proteases that are evolutionarily conserved from prokaryotes to …

Protein folding is important for all life. Indeed, protein misfolding can result in catastrophic
protein aggregation and toxicity. The pathways involved in reversing protein aggregation …

The mitochondrial disulphide relay machinery is essential for the import and oxidative
folding of many proteins in the mitochondrial intermembrane space. Its core component, the …

HtrA2 (high-temperature requirement A2) and GRIM-19 (gene associated with retinoic and
interferon-induced mortality 19 protein) are involved in various biological functions with their …

Background HtrA2, a pro-apoptotic protease, plays a crucial role in apoptosis by cleaving
inhibitory and anti-apoptotic proteins by translocating from mitochondria to the cytosol. Prior …

Vaccinia-related kinases (VRK) are serine-threonine kinases that regulate several signaling
pathways. The isoform-VRK2A of one such kinase VRK2 controls cell stress response by …

Abstract Human High Temperature requirement A2 (HtrA2) also known as Omi, is a serine
protease located in the mitochondria with an important function in both cell survival and …

Abstract Vaccinia-related kinase 2 (VRK2) are Serine-Threonine kinases that regulate
several signaling pathways. Its isoform, VRK2A controls cell stress response by interacting …

(2) Name of the mechanism given by the authors in the quoted reference. α, β and the
inhibition/activation constants for the modifier (X), uniformly denoted KX, are the values …