Systems neuroscience of natural behaviors in rodents
Animals evolved in complex environments, producing a wide range of behaviors, including
navigation, foraging, prey capture, and conspecific interactions, which vary over timescales …
navigation, foraging, prey capture, and conspecific interactions, which vary over timescales …
Rhodopsins: an excitingly versatile protein species for research, development and creative engineering
WJ de Grip, S Ganapathy - Frontiers in Chemistry, 2022 - frontiersin.org
The first member and eponym of the rhodopsin family was identified in the 1930s as the
visual pigment of the rod photoreceptor cell in the animal retina. It was found to be a …
visual pigment of the rod photoreceptor cell in the animal retina. It was found to be a …
Spatiotemporal constraints on optogenetic inactivation in cortical circuits
Optogenetics allows manipulations of genetically and spatially defined neuronal populations
with excellent temporal control. However, neurons are coupled with other neurons over …
with excellent temporal control. However, neurons are coupled with other neurons over …
Tapered fibertrodes for optoelectrical neural interfacing in small brain volumes with reduced artefacts
Deciphering the neural patterns underlying brain functions is essential to understanding
how neurons are organized into networks. This deciphering has been greatly facilitated by …
how neurons are organized into networks. This deciphering has been greatly facilitated by …
Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe
Optogenetic methods provide efficient cell-specific modulations, and the ability of
simultaneous neural activation and inhibition in the same brain region of freely moving …
simultaneous neural activation and inhibition in the same brain region of freely moving …
[HTML][HTML] The anterior cingulate cortex directs exploration of alternative strategies
The ability to adjust one's behavioral strategy in complex environments is at the core of
cognition. Doing so efficiently requires monitoring the reliability of the ongoing strategy and …
cognition. Doing so efficiently requires monitoring the reliability of the ongoing strategy and …
A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC
AJO Lewis, RS Hegde - BMC biology, 2021 - Springer
Background Protein transporters translocate hydrophilic segments of polypeptide across
hydrophobic cell membranes. Two protein transporters are ubiquitous and date back to the …
hydrophobic cell membranes. Two protein transporters are ubiquitous and date back to the …
Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes
J Park, JW Phillips, JZ Guo, KA Martin, AW Hantman… - Science …, 2022 - science.org
The interaction of descending neocortical outputs and subcortical premotor circuits is critical
for shaping skilled movements. Two broad classes of motor cortical output projection …
for shaping skilled movements. Two broad classes of motor cortical output projection …
Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
MA Dreier, P Althoff, MJ Norahan… - Communications …, 2021 - nature.com
Channelrhodopsins are widely used in optogenetic applications. High photocurrents and
low current inactivation levels are desirable. Two parallel photocycles evoked by different …
low current inactivation levels are desirable. Two parallel photocycles evoked by different …
A new theoretical framework jointly explains behavioral and neural variability across subjects performing flexible decision-making
The ability to flexibly select and accumulate relevant information to form decisions, while
ignoring irrelevant information, is a fundamental component of higher cognition. Yet its …
ignoring irrelevant information, is a fundamental component of higher cognition. Yet its …