Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017 - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
[HTML][HTML] Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss
Bone is maintained by coupled activities of bone-forming osteoblasts/osteocytes and bone-
resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …
resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …
Sites of Cre‐recombinase activity in mouse lines targeting skeletal cells
ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …
function and gain‐of‐function studies, as well as lineage tracing, through gene …
Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone
Abstract Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast
progenitors and an important regulator for bone resorption. It remains elusive which …
progenitors and an important regulator for bone resorption. It remains elusive which …
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction
that is essential for bone development, however, how IFT proteins regulate Hh signalling in …
that is essential for bone development, however, how IFT proteins regulate Hh signalling in …
[HTML][HTML] Macrophage regulator of G-protein signaling 12 contributes to inflammatory pain hypersensitivity
G Yuan, S Yang, M Gautam, W Luo… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background Pain is a predominant symptom in rheumatoid arthritis (RA) patients that results
from joint inflammation and is augmented by central sensitization. Regulator of G-protein …
from joint inflammation and is augmented by central sensitization. Regulator of G-protein …
Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring
Background The births of more than 8 million infants have been enabled globally through
assisted reproductive technologies (ARTs), including conventional in vitro fertilization (IVF) …
assisted reproductive technologies (ARTs), including conventional in vitro fertilization (IVF) …
Mouse Cre models for the study of bone diseases
Abstract Purpose Transgenic Cre lines are a valuable tool for conditionally inactivating or
activating genes to understand their function. Here, we provide an overview of Cre …
activating genes to understand their function. Here, we provide an overview of Cre …
Genetic analysis of rare human variants of regulators of G protein signaling proteins and their role in human physiology and disease
KE Squires, C Montañez-Miranda, RR Pandya… - Pharmacological …, 2018 - Elsevier
Regulators of G protein signaling (RGS) proteins modulate the physiologic actions of many
neurotransmitters, hormones, and other signaling molecules. Human RGS proteins …
neurotransmitters, hormones, and other signaling molecules. Human RGS proteins …
Sustained release of chlorogenic acid-loaded nanomicelles alleviates bone loss in mouse periodontitis
H Li, J Xu, JF Hu, QY Hu, X Fang, ZJ Sun, Z Xu… - Biomaterials …, 2022 - pubs.rsc.org
Periodontitis is a prevalent chronic inflammatory disease that destroys the periodontal
supporting tissues, impinges on oral health, and is correlated with an increased risk of …
supporting tissues, impinges on oral health, and is correlated with an increased risk of …