How and where did life on Earth originate? To date, various environments have been
proposed as plausible sites for the origin of life. However, discussions have focused on a …

Antonio Lazcano* and Stanley L. Miller† models incorporate high partial pressures of CO2
to raise the temperature of the Earth by a greenhouse effect* Departamento de Biologıa …

Phosphate is essential for all living systems, serving as a building block of genetic and
metabolic machinery. However, it is unclear how phosphate could have assumed these …

Prebiotic systems chemistry suggests that high phosphate concentrations were necessary to
synthesise molecular building blocks and sustain primitive cellular systems. However …

The origin of RNA is one of the most formidable problems facing prebiotic chemists. We
consider RNA as a product of evolution, as opposed to the more conventional view of RNA …

Now in a second edition, Biochemistry of Inorganic Polyphosphates fills the need for an
exhaustive resource on inorganic polyphosphate metabolism. The authors describe the …

Life is believed to have originated on Earth∼ 4.4–3.5 Ga ago, via processes in which
organic compounds supplied by the environment self-organized, in some geochemical …

Life is made of the intimate interaction of metabolism and genetics, both built around the
chemistry of the most common elements of the Universe (hydrogen, oxygen, nitrogen, and …

Phosphorus is a key biologic element, and a prebiotic pathway leading to its incorporation
into biomolecules has been difficult to ascertain. Most potentially prebiotic phosphorylation …

It has been hypothesized that before the emergence of modern DNA–RNA–protein life,
biology evolved from an “RNA world.” However, synthesizing RNA and other …