Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …

INTRODUCTION Cerebrospinal fluid (CSF) covers and protects the brain from mechanical
injury. CSF also flows along an interconnected network of perivascular spaces surrounding …

Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …

Preeclampsia (PE) is the leading cause of maternal and fetal mortality globally and may
trigger dementia later in life in mothers and their offspring. However, the etiological drivers …

Traumatic brain injury (TBI) has been associated with the development of Alzheimer's
disease (AD) because these conditions share common pathological hallmarks: amyloid-β …

Tau immunotherapies have advanced from proof-of-concept studies to over a dozen clinical
trials for Alzheimer's disease (AD) and other tauopathies. Mechanistic studies in animal and …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Microglia are resident immune cells in the central nervous system (CNS) that originate from
myeloid progenitor cells in the embryonic yolk sac and are maintained independently of …

The multifactorial and complex nature of Alzheimer's disease (AD) has made it difficult to
identify therapeutic targets that are causally involved in the disease process. However …