▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

Ceramide, generated by the action of acid sphingomyelinase (ASM), has emerged as a
biochemical mediator of stimuli as diverse as ionizing radiation, chemotherapy, UVA light …

Accumulating evidence indicates that gut microbiota participates in the pathogenesis and
progression of liver diseases. The severity of immune-mediated liver injury is associated …

IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that
is especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been …

RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally.
However, its potential to treat or prevent disease remains unproven. Fas-mediated apoptosis …

Natural killer T (NKT) cells constitute a distinct subpopulation of T cells with a unique antigen
specificity, prompt effector functions, and an unusual tissue distribution. NKT cells are …

Recent evidence suggests that ceramide regulates stress signaling via reorganization of the
plasma membrane. The focus of this review will be to discuss the mechanism by which acid …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a proapoptotic
member of the TNF family of type II membrane proteins, which constitutes one component of …

The administration of concanavalin A (Con A) induces a rapid severe injury of hepatocytes
in mice. Although the Con A–induced hepatitis is considered to be an experimental model of …

Suppressor of cytokine signaling (SOCS) 3 attenuates proinflammatory signaling mediated
by the signal transducer and activator of transcription (STAT) family of proteins. But acute …