Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

Muscles are essential for movement and heart function. Contraction and relaxation of
muscles rely on the sliding of two types of filaments—the thin filament and the thick myosin …

In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the
underlying mechanism remains nebulous. In this work, we used cryo–electron tomography …

Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

Heart muscle has the unique property that it can never rest; all cardiomyocytes contract with
each heartbeat which requires a complex control mechanism to regulate cardiac output to …

Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …

Classically, striated muscle contraction is initiated by calcium (Ca2+)-dependent structural
changes in regulatory proteins on actin-containing thin filaments, which allow the binding of …

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and
regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point …

Cardiac contraction depends on molecular interactions among sarcomeric proteins
coordinated by the rising and falling intracellular Ca2+ levels. Cardiac thin filament (cTF) …

Cardiovascular diseases refer to a group of the circulatory system disorders, including
atherosclerosis, thrombosis, myocardial/cerebral infarction and the following ischemia …