Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

M1 macrophages induce protective immunity against infection, but also contribute to
metabolic and inflammatory diseases. Here we show that the E3 ubiquitin ligase, MDM2 …

Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …

Abstract p53 regulates several signaling pathways to maintain the metabolic homeostasis of
cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes …

Metabolic reprogramming is a hallmark of cancer with a strong impact on tumor cell survival,
proliferation, dissemination, and resistance to therapy. As such, it has represented a …

Glucose is the key source for most organisms to provide energy, as well as the key source
for metabolites to generate building blocks in cells. The deregulation of glucose …

Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a
barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms …

Glucose metabolism modulates the islet β cell responses to diabetogenic stress, including
inflammation. Here, we probed the metabolic mechanisms that underlie the protective effect …

Liver cancer is the second most frequent cause of cancer-related death globally. The main
histological subtype is hepatocellular carcinoma (HCC), which is derived from hepatocytes …