Reprogramming energy production from mitochondrial respiration to glycolysis is now
considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to …

The SUMO family is a type of ubiquitin-like protein modification molecule. Its protein
modification mechanism is similar to that of ubiquitination: both involve modifier-activating …

Epigenetic mechanisms, including histone post-translational modifications (PTMs), play a
critical role in regulating pain perception and the pathophysiology of burn injury. However …

Background Previous studies have demonstrated that PANoptosis is strongly correlated with
cancer immunity and progression. This study aimed to develop a PANoptosis-related …

Chromobox (CBX) 2, a member of the CBX protein family and a crucial component of the
polycomb repressive complex (PRC), exerts significant influence on the epigenetic …

Previous studies have highlighted the poor prognosis of liver cancer, and treatment effects
are overall limited. We aimed to confirm the biological roles of SIAH2 in liver cancer and …

The Polycomb Group (PcG) complex PRC1 represses transcription, forms condensates in
cells, and modifies chromatin architecture. These processes are connected through the …

Background Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive
malignant tumors. Chromobox (CBX) family plays the role of oncogenes in various …

Background Acute myeloid leukemia (AML) is a common leukemia with low cure rate and
poor prognosis among pediatric patients. The regulation of AML immune microenvironment …

Abstract Chromobox protein homolog 2 (CBX2) exerts a multifaceted impact on the
progression of aggressive cancers. The proteasome-dependent pathway is crucial for …