Chronic kidney disease (CKD) is a major and serious global health problem that leads to
kidney damage as well as multiple systemic diseases. Early diagnosis and treatment are two …

Diabetes is associated with excess morbidity and mortality due to both micro-and
macrovascular complications, as well as a range of non-classical comorbidities. Diabetes …

Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant
tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading …

The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …

Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney
disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Vesicoureteral reflux represents one of the most concerning topics in pediatric nephrology
due to its frequency, clinical expression with the potential to evolve into chronic kidney …

Urinary tract infection (UTI) caused by uropathogens is the most common infectious disease
and significantly affects all aspects of the quality of life of the patients. However …

Epithelial cells secrete apical extracellular matrices to form protruding structures such as
denticles, ridges, scales, or teeth. The mechanisms that shape these structures remain …