Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

In the last decade, ample evidence has demonstrated the growing importance of androgen
receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to …

Compounds that regulate the function (s) of nuclear receptors (NRs) are useful for biological
studies and as candidate therapeutic agents. Most such compounds are agonists or …

OBJECTIVE: To investigate the genetic association between estrogen and progesterone
receptor polymorphisms (ER, PR) and skewed X chromosome inactivation (XCI) and …

The androgen receptor (AR) plays a central role in prostate cancer. Development of
castration resistant prostate cancer (CRPC) requires androgen-independent activation of …

Spinal and bulbar muscular atrophy (SBMA), or Kennedy's disease, is a rare X-linked
neuromuscular disorder predominantly affecting males and caused by a mutation in the …

Preterm birth is the major cause of neonatal mortality and morbidity. In many cases, it has
severe life-long consequences for the health and neurological development of the newborn …

Nine human neurodegenerative diseases, including Huntington's disease and several
spinocerebellar ataxia, are associated to the aggregation of proteins comprising an …

The androgen receptor (AR), oestrogen receptor alpha (ESR1) and oestrogen receptor beta
(ESR2) play essential roles in mediating the effect of sex hormones on sex differences in the …

Huntingtin (HTT) is a scaffold protein mostly known because it gives rise to the severe and
incurable inherited neurological disorder Huntington's disease (HD) when mutated. The …