Mitochondria control various processes that are integral to cellular and organismal
homeostasis, including Ca 2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not …

Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is
fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that …

Idiopathic pulmonary fibrosis (IPF), one of the most common fibrosing interstitial lung
diseases (ILD), is a chronic-age-related respiratory disease that rises from repeated micro …

The Arg/N-degron pathway, which is involved in the degradation of proteins bearing an N-
terminal signal peptide, is connected to p62/SQSTM1-mediated autophagy. However, the …

The transport of live fish is a necessary step for commercial production. The skin of teleost
fish is the first non-specific immune barrier against exogenous stimuli, and it plays an …

Long noncoding RNA (LncRNA), a noncoding RNA over 200nt in length, can regulate
glycolysis through metabolic pathways, glucose metabolizing enzymes, and epigenetic …

The social defeat stress model is commonly used to study depression and anxiety disorder,
which can significantly affect the structure and function of neurons in the hippocampus; …

Dynamic protein complexes function in all cellular processes, from signaling to transcription,
using distinct conformations that regulate their activity. Conformational switching of proteins …

Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in
the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress …

ABSTRACT MFN1 (mitofusin 1) and MFN2 are key players in mitochondrial fusion,
endoplasmic reticulum (ER)-mitochondria juxtaposition, and macroautophagy/autophagy …