Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a
lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Cerebrovascular disease is the third most common cause of death in developed countries,
but our understanding of the cells that compose the cerebral vasculature is limited. Here …

Spinal cord injury leads to a massive response of innate immune cells in non-regenerating
mammals, but also in successfully regenerating zebrafish. However, the role of the immune …

The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …

During development, animals generate distinct cell populations with specific identities,
functions, and morphologies. We mapped transcriptionally distinct populations across …

Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …

The epicardium, a mesothelial cell tissue that encompasses vertebrate hearts, supports
heart regeneration after injury through paracrine effects and as a source of multipotent …

In the dense circulatory system of the kidney, as in all vascularized tissues, pericytes enwrap
capillaries and microvessels to regulate angiogenesis, stabilize microvascular networks and …