PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

F Abedi-Gaballu, G Dehghan, M Ghaffari, R Yekta… - Applied materials …, 2018 - Elsevier
Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …

Crossing the blood–brain barrier: recent advances in drug delivery to the brain

MM Patel, BM Patel - CNS drugs, 2017 - Springer
CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

Dendrimer-based drug delivery systems for brain targeting

Y Zhu, C Liu, Z Pang - Biomolecules, 2019 - mdpi.com
Human neuroscience has made remarkable progress in understanding basic aspects of
functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the …

Recent progress of drug nanoformulations targeting to brain

AR Khan, X Yang, M Fu, G Zhai - Journal of Controlled Release, 2018 - Elsevier
Most of the potential therapeutic agents capable to modulate the pathophysiology or treat
the neurological disorders and brain tumors are useless in the current modern and …

Nanoparticle functionalization and its potentials for molecular imaging

R Thiruppathi, S Mishra, M Ganapathy… - Advanced …, 2017 - Wiley Online Library
Functionalization enhances the properties and characteristics of nanoparticles through
surface modification, and enables them to play a major role in the field of medicine. In …

Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules

S Harilal, J Jose, R Kumar, MK Unnikrishnan… - Brain research …, 2020 - Elsevier
Barriers are the hallmark of a healthy physiology, blood-brain barrier (BBB) being a tough
nut to crack for most of the antigens and chemical substances. The presence of tight …

Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma

M Alibolandi, F Hoseini, M Mohammadi… - International journal of …, 2018 - Elsevier
Gold NPs have great potential in biomedical applications. PAMAM dendrimers are spherical,
hyper branched macromolecules which can encapsulate therapeutic molecules while …

siRNA drug delivery across the blood–brain barrier in Alzheimer's disease

MI Sajid, FS Sheikh, F Anis, N Nasim… - Advanced Drug Delivery …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a few FDA-
approved drugs that provide modest symptomatic benefits and only two FDA-approved …

Hyaluronic acid‐decorated liposomal nanoparticles for targeted delivery of 5‐fluorouracil into HT‐29 colorectal cancer cells

B Mansoori, A Mohammadi… - Journal of Cellular …, 2020 - Wiley Online Library
The use of liposomes as drug carriers improves the therapeutic efficacy of anticancer drugs,
while at the same time reducing side effects. Hyaluronic acid (HA) is recognized by the …

Impaired oligodendrocyte maturation in preterm infants: potential therapeutic targets

E Van Tilborg, CJ Heijnen, MJ Benders, F van Bel… - Progress in …, 2016 - Elsevier
Preterm birth is an evolving challenge in neonatal health care. Despite declining mortality
rates among extremely premature neonates, morbidity rates remain very high. Currently …