Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …

Simple Summary Alterations of the MEK5/ERK5 signaling pathway have been described in
several tumors, and emerging data are trying to explain the complexity of ERK5-related …

Owing to the prevalence of tumor-associated macrophages (TAMs) in cancer and their
unique influence upon disease progression and malignancy, macrophage-targeted …

Malignant melanoma is among the most aggressive cancers and its incidence is increasing
worldwide. Targeted therapies and immunotherapy have improved the survival of patients …

BMP4 regulates a plethora of developmental processes, including the dorsal–ventral axis
and neural patterning. Here, we report that BMP4 reconfigures the nuclear architecture …

Melanoma is the deadliest skin cancer with a very poor prognosis in advanced stages.
Although targeted and immune therapies have improved survival, not all patients benefit …

The hallmarks of stem cells, such as proliferation, self-renewal, development, differentiation,
and regeneration, are critical to maintain stem cell identity which is sustained by genetic and …

Aberrant DNA methylation is a hallmark of cancer. However, our understanding of how
tumor cell-specific DNA methylation patterns are established and maintained is limited …

The presence of immunosuppressive macrophages that become activated in the tumor
microenvironment constitutes a major factor responsible for tumor growth and malignancy. In …

The importance of mitogen-activated protein kinases (MAPK) in human pathology is
underlined by the relevance of abnormalities of MAPK-related signaling pathways to a …